DJEtzel, It looks like you haven't had much experience with this gene:
http://www.germanshepherds.com/foru...rds.com/forum/health-issues/145232-ivermectin-german-shepherds.html#post1940039

As Kris and the above information explaned, some mutant dogs can tolerate the lower doses used at the heartworm preventative level, and not at the higher range. Some dogs may react to even the low doses, it can be somewhat individual. My half-mutant tolerated monthly heartguard without any problems when she was on it.

 

DJEtzel, It looks like you haven't had much experience with this gene:
http://www.germanshepherds.com/foru...rds.com/forum/health-issues/145232-ivermectin-german-shepherds.html#post1940039

As Kris and the above information explaned, some mutant dogs can tolerate the lower doses used at the heartworm preventative level, and not at the higher range. Some dogs may react to even the low doses, it can be somewhat individual. My half-mutant tolerated monthly heartguard without any problems when she was on it.

I haven't had a lot of personal experience with it, but know some people with affected dogs and have read a lot about it since the breed of dog I'm getting in the spring is likely to have it.

But you kind of confirmed what I was saying; it's a case by case basis, whether or not they show issues with it while having the the MDR1 gene?

Are you maybe talking giving straight old Ivermectin and not something like Heartguard? I use Interceptor...

Nice chart:
Dog Heartworm Preventive Products Comparison Chart

I had always assumed while reading that a HW preventative pill like Heartguard was not recommended, and I *believe* that is what the dogs I know where taking that had reactions. I am not positive however.

 

Where did you order it?

 

Petstruly.com
Item Cost
1 Ivomec (1%
Ivermectin)
for Cattle &
Swine, 50 ml $43.99
1 Syringe 1cc
(Tuberculin)
25ga x 5/8,
Regular Luer
EACH $1.98
Subtotal: $45.97
Shipping: $6.95
Tax: $0.00
Total: $52.92

 

The stuff in Interceptor is on the list. I think the other ones might be too, would have to check the link above.

 

What link? The one Jean posted just tells the ingredients in them, not the gene's reaction towards different Hw preventatives.