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I was told the best time to spay a female is at 6 months. You wanna catch her before the first heat.

I don't remember what the best time to neuter males is, but yes, if you don't neuter him, the chance of him getting cancer later on is higher.
 

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Are you saying there are negative effects neutering later?
Yes. It's better to neuter when they're young, unless you don't mind the chances of a massive weight gain. I'm not completely sure it's the same in males, but I've seen a 300 pound rotty due to a much later spay.
 
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