My point was that she threw up 12 hours after giving the pill. Surely that can't be pill related??
Certainly can and probably is.
I have a young dog on cyclosporine/ketoconazole treatment for reoccurring PF. Dog is on a single protein fish based food. Dosed every other day or every 2 days - he will vomit occasionally when given medication. It is not food related and vomiting is associated with administering the medicine. My dog experiences quite a few symptoms with cyclo/keto: extensive hair loss with sped up shed/growth cycles, vomiting, lethargy, diarrhea, mood changes on daily dose that has tapered off as dose lowered. However, it's the only medication that can keep the PF under control and allow him to have comfortable bowel movements so we just have to take the side effects in stride...
Cylcosporine takes a longer period of time to influence a response in the dog and takes awhile to establish standard blood therapeutic levels - one reason why PF dogs are sometimes started off on steroid treatments first combined with Cyclo/Keto as the steroid treatment will result in a quick response with the cyclo taking a longer period of time to enact a change resulting in a two fold approach to quickly bringing the disease under control. I think you should discuss the addition of ketoconazole to your treatment plan as keto allows you to drastically lower the dose of cyclo which will be much more cost effective for you. Cyclo is cleared fairly quickly and efficiently by the liver - through a mechanism not entirely clarified yet, keto allows for slower clearance of cyclo by the liver meaning the cyclo stays around in the blood for longer at a higher therapeutic dose than without concurrent keto administration. Allows you to give a smaller dose of cyclo and save money on treatment. Most/all recent literature cites cyclo/keto treatment as the best option for PF right now.
Good general game plan for a PF dog:
-clip and shave the hair around the perianal area. Let the area breathe so bacteria is not trapped by the hair.
-wipe the dog with a baby wipe after bowel movements. Helps clear the area of local bacteria
-spray the perianal area with Vetericyn and apply Desitin to the fistulas.
-continue with cyclosporine treatment until you start to see complete elimination of the fistulas. Keep the dog on the meds for at least one month after you see complete disappearance of the external PF as the deep tunneling tracts of PF can extend very deeply into the dog's viscera and you want to make sure there is complete reduction of the fistulas.
-Once the PF are under control, find a maintenance dose that works for your dog. I've known dogs that never needed to be on cyclo again after one round of treatment, and there are dogs that need to be on the meds the rest of their lives. Will have to fine tune and see what works.
-regular blood/liver panels to monitor the dog as the medication can cause issues in some dogs
-single protein diet. Avoid changes or numerous sources/additions. Adding bulk and probiotics can be helpful
-I don't vaccinate my PF dog at all.