Well, we've been on previcox and tramadol for a while with Midnights arthritis. The previcox does virtually nothing as there really isn't a difference between him on it or off it. My regular vet is adamant on keeping him on previcox as it is the supposed safest of the NSAIDs. Anyways, my holistic vet who also does western medicine is willing to switch NSAIDs as the previcox isn't working. He is getting accupuncture which does help and adequan that helps a lot but is on backorder. Anyways, what do you guys think of metacam? I know from experience that some dogs respond differently to different NSAIDs. Some have a marked response to rimadyl and not to deramaxx and vice versa. Midnight is also getting glucosamine chondroitin supplements, hyaluronic acid, msm, fish oil, vit e and Chinese herbs. He is on once weekly adequan and I'd due for a loading dose in July. I have enough for that thank goodness. He also gets tramadol and previcox. If I do switch the previcox, I'll do a week long flush before starting metacam. His bloods were excellent so no liver or kidney compromise. Just really checking to see if anyone has had success with metacam. I'm disappointed that previcox doesn't work, but that doesn't mean all NSAIDs won't work.