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I don't know about pain, but they can sure be nuttier than a fruitcake while in heat.
Some of them, you would swear, completely lose any coherent thought process for the duration.
 

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It's very common for people to have extra Rimadyl on hand as it's given out on an as needed basis for a lot of injuries or surgeries so there's frequently some left. I had a dog with an intermittent chronic problem and the vet did just hand out a bottle of it for me to use as needed.
 
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