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Cava, floofy supermodel
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I don't know about pain, but they can sure be nuttier than a fruitcake while in heat.
Some of them, you would swear, completely lose any coherent thought process for the duration.
^ This. My girls have been mopey, scatterbrained, easily distracted, and sometimes clingy when in heat. I wouldn't give medication without an obvious sign of pain (for any condition), and have never done anything special to comfort them.
 
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