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Discussion Starter #1
I thought some of you that have Mutant/Mutant dogs might find this helpful.

I received an email via my vet from WSU stating that dogs with the MDR1 mutation can have relative adrenal insufficiency (lower basal cortisols and lower basal ACTH concentrations than dogs that do not have the MDR1 mutation) They haven't tested Mutant/Normal dogs, but they could suffer from the same issue as Mutant/Mutant dogs.
Comparison of the hypothalamic–pituitary–adrenal axis in MDR1-1[] and MDR1 wildtype dogs - Mealey - 2006 - Journal of Veterinary Emergency and Critical Care - Wiley Online Library

The WSU vet indicated that doing a ACTH stim test might be useful.

The WSU vet also said "Research mice that have had the MDR1 gene genetically “knocked out” have a higher incidence of inflammatory bowel disease than “normal” mice."
 

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Discussion Starter #3
Interestingly enough, Remy has been diagnosed with Atypical Addisions. I'm not quite sure what relative adrenal insufficiency is (I think it's another name for Addisons?), but I need to run this by the specialist. I had forgotten I posted this way back!
 
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