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My advice would be to separate them, at least while you are working with them. If you can crate them separately, but next to each other that would be even better.

Take them individually into a different part of the house and work with them for a few minutes many times throughout the day.

The shelter I worked with for years had a few litters like you describe, and they can be worked with. It takes time and patience and not every pup (even from the same litter) will come around and be adoptable. But it can be done.

Good luck. I'll be interested in hearing how it goes.
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