My male would freak out when we left, and we had him in a crate large enough for him to completely spread out and relax. What we found was he would go to one area of the crate and potty, then try and sleep in the other. It also got to the point where even in a smaller crate, he’d just stand up and pee.Can you elaborate on your exact procedure? I do have her in a Great Dane crate. It is gigantic. Big enough for a human to sleep in. However lately I have been giving her an entire bedroom to play in when I leave. I'll have to get a smaller crate.
So we gave him very restricted water access at night. Throughout the day while we were home he could drink as much as he wanted, but then we’d take him out every 30-40 minutes. After about 7-8 PM, he received no water whatsoever, and we started taking him out 1-2 times in the night. This is more crate/potty training than anxiety though.
For his anxiety, we covered his crate and made sure to use an airline crate so he felt safe. We’ve found that the dogs don’t like the wire crates and don’t go into them to rest, whereas the airline crates they all walk into and relax out of personal choice. We played TV episodes loud enough so he couldn’t hear us leave, about 10 minutes before so it didn’t perfectly coincide with us going.
Over time he gradually became accustomed to the crate and the potty accidents stopped, as did his total freak outs. He still is a crate crier every now and then, but it’s a night and day different from before.