Yes we are going on our 3rd season using it on both our gsd's and 3 cats too. It does every bit that Fronline plus did we are very pleased with it. Only thing we noticed it seems to take a little longer to be absorbed, but otherwise we like the results.
The new edition is supposed to be more effective, and the ingredient list is the same as Advantage and Frontline (combines some of their ingredients), so I don't think you'll get the reactions people had out of the old Biospot.
That said, I did not find it to be effective on my dog, and Advantage was only partially effective. My dog is on Frontline Plus now.
I think most of the spot-ons work by the oils in the coat distributing the substances. If your dog tends to have a dry coat, or probably even a dirty one, then I suspect that none of them will be very effective.
I always give a bath about a week before application to increase the ability of the stuff to distribute.
I think I'm going to try it, it seems more reasonable than the Frontline Plus. And, since I definitely WILL NOT be buying the Promeris again maybe this stuff will be okay. I really prefer K9 Advantix but the price on that stuff has gone WAY UP!
I got all excited checking the prices on this and comparing to Advantage. But then I looked at the active ingredient in the BioSpot for dogs and it is, I THINK, stuff you can't use on cats/around cats. So with cats who groom dogs, I don't believe that this is something I can use (just like I can't use Advantix). Poop. I guess I could buy the cat stuff for the cats and save money there...maybe.
For the first 3 or so years I was using BioSpot on my dogs, my sister and her 2 cats were leaving with us. Her cats never had issues with it, and the male cat use to wrestle with my Yorkie who had Bio on her.