Megaesophagus and Breeding the Carrier - German Shepherd Dog Forums
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post #1 of 132 (permalink) Old 08-06-2012, 03:04 PM Thread Starter
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Megaesophagus and Breeding the Carrier

So, a pup has come down with primary idiopathic megaesophagus. This is a genetic disease which genes are passed by both parents. The breeder that owns the dam has retired her and she will be getting placed into a pet home. This was her first litter. The sire's owner is not acknowledging that their dog carries the Mega E gene and has continued to set up more breedings with this dog. It is the belief that the sire's owner is not telling the bitch's owners that the dog has produced a Mega E pup. This is the sire's second litter.

What would you do?

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post #2 of 132 (permalink) Old 08-06-2012, 03:58 PM
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I would put the pup's pedigree on the PDB and list the megaesophagus issue. That way people researching pedigrees can be aware.

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post #3 of 132 (permalink) Old 08-06-2012, 04:55 PM
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I wouldn't throw the baby out with the bathwater. Like all health issues, it has to be weighed in terms of many other factors. There are also far worse issues that a dog could produce than MegaE. Especially if it is a mild case that the dog outgrows. Severity, frequency of occurrence, and what the dogs have to offer in terms of other temperament and health traits to their pups all need to be taken into consideration.

We had ONE pup in a litter of 9 with MegaE. Jenn's Glory. She outgrew symptoms in puppyhood. No other pups in the litter were affected. Neither sire nor dam was retired due to that one pup. The dam had one more litter with a different sire, 11 pups, no MegaE. So 20 pups total from the dam, only 1 MegaE. The sire has had several other litters to total many dozens of pups, with several different dams, all with no MegaE. Two full sisters and one half sister of the dam have also been bred, producing several other litters between them, with no MegaE in any of those either.

So there would certainly appear to be much more complexity to the inheritence of this disorder than a simple autosomal recessive as some believe. And it's not impossible that as with other similiar disorders, inheritance in one breed isn't the same as in other breeds. Regardless of means of inheritance, people have to keep the total dog in mind as well as overall production record. If every dog is eliminated from breeding if it produces one undesireable trait or pup, even if pretty severe, there won't be many dogs left to breed.


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post #4 of 132 (permalink) Old 08-06-2012, 07:44 PM Thread Starter
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They have actually figured out more on the inheritance portion of ME in regards to GSD's. If a dog actively has ME and is bred, it only takes that one parent. If not, then both the sire and dam have to have the gene to pass it to the pups. So if the dogs are still being bred, they continue to pass the gene on and make more carriers.

Why is it different with ME than it is with hip displaysia? If a dog has severe hip displaysia then the dog would not (or at least should not) be bred. Wouldn't that be considered taking dogs out of the gene pool as well?

SBD Posejpal's Leyna, HCTs 6/16/2010
SBD Posejpal's Hades, 5/9/12

At the rainbow bridge:
Zappa 12/27/00-1/23/12 You are my heart, my soul, and my best friend. You will be with me always.
Zeus 5/9/12-8/13/12 You taught me strength. Run free.
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post #5 of 132 (permalink) Old 08-06-2012, 07:51 PM
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Is there published data available about the inheritance of mega-E?

As someone who had a dog with it, and who has raised puppies with it.... it can be a heartbreaking disease.

Chris- At what point did you know Glory had Mega-E?
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post #6 of 132 (permalink) Old 08-06-2012, 07:54 PM
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I don't know alot about mega e on how it's passed. But I see in your first post you said that "BOTH" had to have the gene to pass it on? If this is so, who's to say if bred to a different sire/dam that it would ever happen again??

Is there a 'test' to see if a dog is a meg e carrier? I mean how do they "know" for sure that both dogs are mega e carriers?

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post #7 of 132 (permalink) Old 08-06-2012, 08:05 PM Thread Starter
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Quote:
Originally Posted by JakodaCD OA View Post
I don't know alot about mega e on how it's passed. But I see in your first post you said that "BOTH" had to have the gene to pass it on? If this is so, who's to say if bred to a different sire/dam that it would ever happen again??

Is there a 'test' to see if a dog is a meg e carrier? I mean how do they "know" for sure that both dogs are mega e carriers?

There is no test yet. Clemson university is currently working on it, but they are still in the early stages.

If there was a test, it would be easy. Carriers breed to clear, no breeding of affected. Too bad it isn't that easy.

SBD Posejpal's Leyna, HCTs 6/16/2010
SBD Posejpal's Hades, 5/9/12

At the rainbow bridge:
Zappa 12/27/00-1/23/12 You are my heart, my soul, and my best friend. You will be with me always.
Zeus 5/9/12-8/13/12 You taught me strength. Run free.
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post #8 of 132 (permalink) Old 08-06-2012, 08:19 PM
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DM tests are not as accurate as once thought, either.

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post #9 of 132 (permalink) Old 08-06-2012, 08:25 PM Thread Starter
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Quote:
Originally Posted by onyx'girl View Post
DM tests are not as accurate as once thought, either.

That is true. However, it is better than absolutely nothing.

SBD Posejpal's Leyna, HCTs 6/16/2010
SBD Posejpal's Hades, 5/9/12

At the rainbow bridge:
Zappa 12/27/00-1/23/12 You are my heart, my soul, and my best friend. You will be with me always.
Zeus 5/9/12-8/13/12 You taught me strength. Run free.
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post #10 of 132 (permalink) Old 08-06-2012, 08:28 PM Thread Starter
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Quote:
Originally Posted by gagsd View Post
Is there published data available about the inheritance of mega-E?

As someone who had a dog with it, and who has raised puppies with it.... it can be a heartbreaking disease.

Chris- At what point did you know Glory had Mega-E?

http://www.akcchf.org/news-events/li...update0909.pdf

Megaesophagus - Clemson Canine Genetics

SBD Posejpal's Leyna, HCTs 6/16/2010
SBD Posejpal's Hades, 5/9/12

At the rainbow bridge:
Zappa 12/27/00-1/23/12 You are my heart, my soul, and my best friend. You will be with me always.
Zeus 5/9/12-8/13/12 You taught me strength. Run free.
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