Iíll apologize in advance, for any typos/incoherence. Not enough coffee on board and Iíve got to jump on a call in 20 (oops 15) minutes, but wanted to respond quickly to a couple of questions/comments raised by OP and LuvShepherds.
@Opsoclonus This makes sense for why the average onset of GDV in dogs is around the age of seven yoa.
Yes, but keep in mind that this is an average age at onset; you really have to look at the variance to get an idea of what one/you might encounter with an individual/your dog ó in the context of other hypothesized contributors (e.g., heritability & consanguinity indices, environment and management practices, temperament/personality) only some of which are controllable. One of the frustrating aspects of this kind of research (well, for me, anyway) is that the more you learn, the more you realize how very much you do not know
. In a slightly OT vent: Another frustration is that too many breeders are not as forthcoming as one might wish them to be about demonstrably heritable problems in their lines ó assuming that they attempt to compile that information in the first place. All the more reason to choose your breeder carefully.
@Opsoclonus This autoimmune disorder leads to dysbiosis of the GI microbiome → IBD in these dogs. Are GSD's prone to IBD?
Genetic Research on IBD: https://www.purinaproclub.com/resour...new-treatments
Canine Breeds at High Risk for IBD: https://www.ncbi.nlm.nih.gov/pubmed/21896567
How to Cure IBD in Dogs: https://nextgendog.com/ibd-in-dogs/ Note that the title is a bit of a misnomer (e.g., ďCureĒ), but has useful information nonetheless.
@Opsoclonus The second article assumes a high degree of consanguinity, which of in itself is problem.
Yes it is. Though, I must confess that the nerd in me has always been fascinated (in a purely intellectual sense) by linebreeding, theory and practice. That said, Iíve also been greatly concerned by the results of linebreeding that Iíve seen ó largely produced by Ďbreedersí whose understanding of genetics could only be described as, uh, romantic. Iím not speaking of GSD breeders, here, as I donít know enough to comment in this specific respect.
@Opsoclonus Since the samples in this experiment are Great Dane's I would be curious to know the the ratio of IBD in Great Dane's to GSD's.
In reading the article we should keep in mind the risk of GDV is Great Dane > Saint Bernard >
Weimaraner > Irish setter > Gordon Setter.
Iíve seen mentions of a GSD study, as @Jax08
noted, but donít have any references to hand and no time to rummage around for any until this evening. If Iím able to find something, Iíll come back and edit it in.
Regarding breed predisposition, there are two things to keep in mind. First, most of that data is limited by self-report. (See my above comments about breeder forthrightness). For example, GDV is not uncommon in wolfhounds and my own experience is illustrative. Yet, the breed frequently doesnít appear in incidence/predisposition lists. It is what it is. So, with additional data, more breeds may show up. Second, itís important to keep in mind that while certain breeds may be more predisposed to GDV, virtually any dog can develop this.
: I tried reading those studies and got bogged down in terminology. Is there anything in the studies that offers advice on how to prevent it? There is discussion of make up of stomach enzymes. Would probiotics or something else help prevent it?
Well, there is rather a LOT of opaque terminology. LOL. To my knowledge, no one really knows
what causes GDV, though it seems clear (IMO) that thereís no one, easily identifiable cause ó which makes it really difficult to talk about prevention. Thatís also why there have been separate lines of investigation. There are several recommendations in the lay literature (e.g., avoid exercise before and after feeding, donít use raised bowls) but many of those arenít supported by current studies ó too many exceptions.
DISCLAIMER: I am not a vet, nor a breeder or a geneticist, yada yada; Iím also speculating in what follows. Since weíre basically talking about gastric issues here (GDV, IBS, IBD), I would and have put my dogs on viable probiotics as SOP, changing which probiotics I use as I gain more information. I look at it this way: It canít hurt, itís likely to boost the dogís immune system, which is a good thing (Iím on probiotics myself), and it may
act prophylactically with GDV in certain cases. (Oh, note that when I say ďviable probioticsĒ I mean probiotics for which there is supportive, scientific data; many/most donít have that).
That said, I believe that the most effective things that dog owners can do are (1) learn the symptoms of GDV, (2) keep simethecone on hand/in the car for immediate use in an emergency, and (3) in consultation with your vet, record the proper dosage for each dog in the household and put that information in the same packet. GDV is a life threatening emergency
. If you suspect that your dog is bloating, do not hesitate. Administer the simethecone immediately and head for the ER. When you get there, tell staff what you administered and when.
@LuvShepherds The genetic link seems to be strongest in direct descendents, so father to son. It doesnít seem to be as strong a correlation when it is more than one generation removed.
Yes, but personally, I wouldnít take overmuch comfort in what one might call a Ďdistance hypothesis;í that is, the further removed a pup is, generationally speaking, from a known case, the safer the pup is from GDV. We just donít know enough yet, certainly this nongeneticist doesnít. For example, later studies may identify what are currently unknown factors and, in turn, that information could boost the coefficient considerably. Weíve known for some time GDV is heritable, but still we donít know all of the setting conditions for genetic transmission never mind expression (GDV itself). Then too, thereís always the pesky problem of epigenetics...
Hope this helps; post questions if anything I said was unclear.