Seems to depend on what the dog inherited (e.g., immune system genes) among other factors. There's been a lot of groundbreaking research on this in recent years and well worth a look. I've listed a couple of articles below.
OP, I don't know nearly enough about pedigrees, per se
, to tell you anything at all useful. However, having had 3 IWs who developed GDV (2 made it, 1 didn't), I would RUN upon finding that GDV (which is
heritable) is present in the generations behind a pup I was considering.
Canine Gut Microbiome Associated with Higher Risk of GDV:
Genetics of GDV in Dogs: https://www.vin.com/apputil/content/...=12513&print=1
Thanks for your input Aly, and yes, I'm increasingly hesitant to move forward.
I've been speaking with many breeders and they're all so ready to shower me with their breadth of knowledge without any expectations.
It's a very different experience from when I met with this breeder and his level of knowledge.
I wish I understood how to read a pedigree with more proficiency, but as I speak to more breeders, I learn something new everytime.
Unfortunately I put down a deposit which I may have to lose. Additionally, waiting for the next & right litter may be a longer wait than I had hoped for.
I appreciate the link to the articles, they're very informative.
I've been reading a lot about ghrelin and motilin mutations/dysfunction to be the main investigation into the cause of GDV. This makes sense as they are the hormones which control the activity of the GI. A malfunction in motility allows for fermentation and production of gas, similar to the implications the article describes.
The NCBI article speaks about the canine genetic HLA as a possible factor in the development of GDV. This is related to an autoimmune mechanism which is a lot like Type II DM in humans: there is a strong genetic predisposition but an environmental factor must also be present in order for expression of the disease.
This makes sense for why the average onset of GDV in dogs is around the age of seven yoa.
This autoimmune disorder leads to dysbiosis of the GI microbiome → IBD in these dogs. Are GSD's prone to IBD?
Since the samples in this experiment are Great Dane's I would be curious to know the the ratio of IBD in Great Dane's to GSD's.
In reading the article we should keep in mind the risk of GDV is Great Dane > Saint Bernard >
Weimaraner > Irish setter > Gordon Setter.
This is good news as there are many environmental/modifiable factors that we are aware of.
I'm excited to see such in depth investigation into this disease, it exemplifies the value of man's best friend.
The second article assumes a high degree of consanguinity, which of in itself is problem.