FDA Alert About Flea/Tick Products & Effects - German Shepherd Dog Forums
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post #1 of 15 (permalink) Old 09-21-2018, 10:18 AM Thread Starter
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FDA Alert About Flea/Tick Products & Effects

Animal Drug Safety Communication: FDA Alerts Pet Owners and Veterinarians About Potential for Neurologic Adverse Events Associated with Certain Flea and Tick Products 9/20/18 https://www.fda.gov/AnimalVeterinary.../ucm620934.htm

Condensed info per TAPF
What should I know?
  • The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration when choosing flea and tick products for their pets.
  • Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats;
  • Although most dogs and cats havenít had neurologic adverse reactions, seizures may occur in animals without a prior history;
  • Many products are available for prevention and control of flea and tick infestations. You can discuss all options with your veterinarian to choose the right product for your pet.

What products are in the isoxazoline class?
  • The FDA-approved drugs in this class are
    • Bravecto
    • Credelio
    • Nexgard
    • Simparica
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post #2 of 15 (permalink) Old 09-21-2018, 01:44 PM
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post #3 of 15 (permalink) Old 09-21-2018, 01:49 PM
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I remember seeing reviews online and hearing from people about issues like this. I'm glad the FDA is putting out an alert...at least they are acknowledging there is an issue for some animals. I have hesitated to use Bravecto and similar products because of what I was hearing. Seresto collar works well for us here so I will stick with that for now.

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post #4 of 15 (permalink) Old 09-21-2018, 03:55 PM
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Our vet actually prescribed Nexgard and we've been using it.
I will ask her to see what she thinks!

The Seresto collars...
I was hesitating because Rumo has an incredibly thick neck ruff (more husky-thickness than GSD thickness - he actually has layers of fur that hang from his neck) so I was wondering if enough of the chemical would penetrate to be effective...

Rumo ~ rescue shepherd/husky mix
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post #5 of 15 (permalink) Old 09-21-2018, 09:45 PM
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Thanks Moms, I was reluctant to give Nexguard per my 'holistic' vet but did for a few months. Fortunately wondercide has been working.

I like the Seresto collars but they make my pup itch her neck.
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post #6 of 15 (permalink) Old 09-21-2018, 09:57 PM
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My vet office tried to sell me Simparica. I declined. Not a fan of ingestables. Frontline works fine for my two.
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post #7 of 15 (permalink) Old 09-21-2018, 10:06 PM
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This part of the warning is pretty important:

"The FDA carefully reviewed studies and other data on Bravecto, Credelio, Nexgard and Simparica prior to approval, and these products continue to be safe and effective for the majority of animals. The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the information they need to make treatment decisions for each pet on an individual basis. Veterinarians should use their specialized training to review their patients’ medical histories and determine, in consultation with pet owners, whether a product in the isoxazoline class is appropriate for the pet."
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post #8 of 15 (permalink) Old 09-22-2018, 01:49 AM
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Oh dear. My boy been with Bravecto for 2 months now, got it from the vet. About to have some more next month... I should talk to the vet...
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post #9 of 15 (permalink) Old 09-22-2018, 08:30 AM
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All of these products tell you not to use on animals with a history of seizures. It's well known, at least to vets and staff, at least it should be.

That said, I have used Nexguard and Bravecto on my seizure having lab and have no issues.

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post #10 of 15 (permalink) Old 09-22-2018, 11:34 AM
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Originally Posted by gsdsar View Post
That said, I have used Nexguard and Bravecto on my seizure having lab and have no issues.

We've used a lot of Nexguard in our rescue too -- and we're dealing with dogs without any known vet history, often in terrible shape. We tend to have more than our share of crazy side-effects on a huge range of drugs pop up simply because of the population we're vetting, and the lack of a history.

When dogs show up covered with ticks, it's so important for us to use something effective that will get all of them, even hard-to-find tiny ones in little nooks and crannies that even careful exams can miss. Nexguard has been really helpful for those dogs. It's also been wonderful for off-label use treating bad demodex in HW+ dogs (where high-dose ivermectin isn't possible).

We've also used Bravecto to a lesser degree. We haven't had side effects from it either, but we have a smaller sample size to compare.

It's worth remembering that Trifexis/Comfortis also has seizure/adverse event reports. We've had whole threads about the weirdness of the unpredictability of which ones react to that product.

Frontline has other issues -- the EPA classified it as Group C (possible human carcinogen) based on rat studies finding increased thyroid tumors (though my recollection is that the rats were fed fipronil at high doses). I also have a vague recollection of some osteosarcoma correlation too, but I can't put my hands on the research right now and might be mis-remembering. Here's the official Fipronil info:
Fipronil Technical Fact Sheet

Ticks transmit awful diseases that can kill dogs, or destroy quality of life. Tick diseases aren't always easy to treat. Fleas aren't just annoying -- an infestation can suck enough blood to make a dog anemic, and even kill puppies (and even mild cases can still transmit other parasites or trigger allergic reactions that are absolutely miserable). For those in warm climates where EOs just aren't enough protection against really voracious bugs, not using parasite prevention has its own dangers too. So please try to keep a balanced perspective and talk with your vet about your dog's history, your environmental concerns, and the disease profiles in your area, to make good, evidence-based decisions for your individual dog!
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Last edited by Magwart; 09-22-2018 at 11:39 AM.
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