Goldenseal tea. there are others. search "Berberine" tea's...natural antibiotic properties. you can apply by making the tea, leave bags in (1 bag per cup of water) bring to room temp...how depends on what you are using for...localized hotspots? all over itchies? can make a rinse after shampoo leave on or sponge into the fur....for hot spots depending where you may be able to secure the tea bag to the spot with some kind of tie. the leg I used a childs sock (white cotton), cut the toe out, the heal part slips nicely over the elbow and the elastic part hold in place around the wrist (carpal). paws you can soak (if will let) in warm tea and epsom salts (tblsp)...you can add touch of ACV too...but if raw this may sting initially although will feel good after a minute, but may give neg. assoc. depends on your dog...wrapping the paw with strips of cotton cloth (t-shirt) and then slip a childs sock over - let soak in for 20mins or so, get back if this isn't helpful, try to find solution.