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Old 03-12-2014, 11:19 AM   #1 (permalink)
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Default Prozac?

Renji is getting Prozac today. While we are hoping it will help with anxiety and aggression, there is also concern that the SSRI will make things worse. We were told to expect about six weeks for improvement but I've ran into a few articles that said negative impacts could be seen far quicker. For those of you who have used Prozac (fluoxetine) on your dogs, what have you noticed? Prescription mood-altering medication is mostly uncharted territory for us; he did react very poorly to Anxitane. Rescue Remedy and Springtime's Stress Free Calmplex do help but not nearly enough.
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Old 03-12-2014, 11:49 AM   #2 (permalink)
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Ashwagandha is calming herb, works with the adrenal glands, thyroid and has immune modulating effects...could see results in as little as 5 days.

Has your dog had a thyroid test?
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Old 03-12-2014, 12:18 PM   #3 (permalink)
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Several times and thyroid always comes back fine. :/ That sure would be an easy fix! I will check into the herb, thank you.
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Old 03-12-2014, 12:44 PM   #4 (permalink)
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Some links

Scientific basis for the therapeutic use of W... [Altern Med Rev. 2000] - PubMed - NCBI

Ashwagandha | GreenMedInfo | Substance | Natural Medicine

Ashwagandha: Stress Reduction, Neural Protection, and a Lot More from an Ancient Herb - Life Extension

^^^
Ashwagandha, an exotic Indian herb, has remarkable stress-relieving properties comparable to those of powerful drugs used to treat depression and anxiety. In addition to its excellent protective effects on the nervous system,

Other studies of chronic stress support these findings. For example, in a remarkable animal study, examination of the brains of sacrificed animals showed that 85% of the brain cells observed in the animals exposed to chronic stress showed signs of degeneration. It is this type of cellular degeneration that can lead to long-term cognitive difficulties. Amazingly, when ashwagandha was administered to chronically stressed animals, the number of degenerating brain cells was reduced by 80%!3
In one of the most complete human clinical trials to date, researchers studied the effects of a standardized extract of ashwagandha on the negative effects of stress, including elevated levels of the stress hormone cortisol. Many of the adverse effects of stress are thought to be related to elevated levels of cortisol. The results were impressive. The participants subjectively reported increased energy, reduced fatigue, better sleep, and an enhanced sense of well-being. The participants showed several measurable improvements, including a reduction of cortisol levels up to 26%, a decline in fasting blood sugar levels, and improved lipid profiles. It would appear from this study that ashwagandha can address many of the health and psychological issues that plague today’s society.4
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Old 03-12-2014, 12:51 PM   #5 (permalink)
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My niece's mixed breed was on Prozac for some years. (mix included Chow or Shar Pei) It definitely helped to ease his anxiety although he remained an easily stressed & reactive guy. She also did training & behavior modification with him. He wore a snug shirt designed to decrease stress as well. With the Prozac he was more manageable for some yrs.

Regrettably, his inappropriate, unpredictable aggression increased with age, & she was eventually forced to have him pts at 8/9 yr old. It was herartbreaking but I think the combination of meds & training helped to give them the years they had together, which while not easy were in many ways good for both of them. She tried herbal remedies but the Prozac worked considerably better.
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Old 03-12-2014, 02:06 PM   #6 (permalink)
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Quote:
Originally Posted by DianaM View Post
Renji is getting Prozac today. While we are hoping it will help with anxiety and aggression, there is also concern that the SSRI will make things worse. We were told to expect about six weeks for improvement but I've ran into a few articles that said negative impacts could be seen far quicker. For those of you who have used Prozac (fluoxetine) on your dogs, what have you noticed? Prescription mood-altering medication is mostly uncharted territory for us; he did react very poorly to Anxitane. Rescue Remedy and Springtime's Stress Free Calmplex do help but not nearly enough.
Woolf is on flouxetine now. We quickly saw improvement in his sleeping habits. He was always on - alert, ready to jump even in sleep - I believe it was the 3rd or 4th night, he zonked out, completely relaxed and slept good. First time I had ever saw him completely relax and get some good sleep. That was during the period he was on the full dose for his weight, which we quickly realized was to much, so dropped it by 2 mg.

It took about 3 weeks to see significant improvement in his ability to absorb the behavioral training and begin learning coping skills. He is now on a much reduced dose and very slowly reducing it more. He is still a very managed dog, but very different then what he used to be.

There is the possibility of this drug class to have the opposite effect - increased aggression, irritability, sleeplessness, lack of appetite. From the research the vet and I did, Clomicalm (the other drug being considered for use) had a higher rate of this happening then with flouxetine. For Woolf, the side effect that we had to deal with for a time was lack of appetite. The appetite issue did appear quickly

Definitely stay on top of the liver, kidney and thyroid functions. It is recommended to check once a year, Woolf's is checked more frequently.
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Old 03-12-2014, 02:24 PM   #7 (permalink)
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Zeeva has taken klonpin (sp) and Benadryl to ease her anxiety during a long road trip. We saw her anxiety worsen almost immediately on both...

I've read that it cam be pretty helpful so I hope it works out well for you guys.

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Old 03-12-2014, 02:32 PM   #8 (permalink)
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Skadi is on it and it seems to really help her. She did have a loss of appetite at first. We want to wean her off of it eventually.
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Old 03-12-2014, 04:09 PM   #9 (permalink)
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Ruby, Twyla, Emily, all very hopeful posts, thank you for sharing. Zeeva, that's what we've seen on at least one natural anti-anxiety which is what worries me. We're crossing fingers here for better results. We will definitely run bloodwork yearly. He does have SOMETHING going on so I'm sure we'll be running more tests soon, anyway.
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Old 03-12-2014, 04:20 PM   #10 (permalink)
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Just curious but is the anxiety/aggression all the time, or in certain instances? Since Renji is 6 years old, is it a recent development?

Have you tried training or a behavioralist?

Keep us posted will you...?
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