I think the OP is talking about liquid ivermectin such as Ivomec brand. There are two issues to be concerned about. First, some dogs have a gene mutation in the MDR1 gene. You can have your dog tested for this issue. Second, it is tricky to get the dose right. If you are using the 1 percent ivermectin solution, the dose is a small fraction of a ml. I don't remember exactly how much. However, if your dog doesn't have the MDR1 mutation, giving a little more than is found in Heartgard shouldn't be a problem. If I were going to do it, I would give 0.1 ml (once a month) of the 1 percent solution, which is more than the Heartgard dose, but safe.
I had a dog on 0.6 ml daily for demodex mange and she had no side effects.
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Last edited by Zookeep; 11-07-2013 at 10:56 PM.