Not real excited with the price of Trifexis, but it was given to us as an alternative to Sentinel which is currently out of production. For now, being winter in a cold climate, the vet gave us Heartgard Plus for 4 months and I will give Hank the last dose I have of Trifexis in May. By then, I am hoping Sentinel will be available again. My breeder had pushed Revolution but I found it extremely messy and felt like most of it ended up dried up in his fur rather than on his skin. Also very expensive. I am supposed to use Frontline if we see any fleas; hoping that won't happen during the winter months.
I really do prefer the pills that combine heartworm and flea protection, but the vet is not stocking Trifexis at this time. I decideded to try the Heartgard Plus for the winter months and it is a huge savings over Sentinel or Trifexis.
I haven't had any vomiting or other adverse reactions with Trifexis, I make sure to give it with his meal.