I moved this to the health section in the hopes you might get some more science based or research based answers.
I am so sorry about Bianca.
I would take a look at some of the lists of congenital disorders that dogs get, by breed. Obviously you/everyone knows about cancer in Goldens.
There are some breeds that might not have that kind of genetic burden.
CIDD - Dog Breeds List
2004 so could find more updated info perhaps - but compare the list of a Schipperke to the GSD just to get an idea of the wide differences (and of course, some things like HD aren't generally life threatening so compare apples to apples).
I think vets and vet hospitals might have some good thoughts on what they see.
I would look at less popular breeds, but also breeds that are not so inbred or bottle necked that things pop up w/great frequency (vWillebrands type things). Then the lines - there are some people on this board who could probably name what dog passed from in pedigrees (when known). I am betting you could find that in other breeds.
Mixes are awesome - but who knows. I deal with the "who knows" for the interesting temperament and behavior and hope the health holds out. So far I am at 50-50 on that (both dogs though very healthy with no issues until the end, the end for one was a few years earlier than expected).
I don't know lifespan of a Malamute - they can be same sex dog aggressive, but should be very people friendly...
Illinois Alaskan Malamute Rescue Association - Home
Some hounds are larger, friendly, happy dogs? Greater Swiss Mountain Dog? Leonberger?
Temperament is also part of health.
Good luck in your search to find a friendly, healthy dog!