DM and Breeding

pwinters · 01-10-2012, 04:21 PM

Hi, new to the forum. What great information I've found here. Forgive me if I ask a question already asked. I tried searching but the results for DM were overwhelming.

We lost our GSD to DM last year at the age of 7. It came on fast and was aggressive. I do not want to go through that again.

My question, there is a breeder in my area who has their male listed as gene tested with a DM result of normal/normal. From another post I found, would this indicate that in the worst case, a puppy I receive from their litter would only be a carrier? And if I had no plans of breeding, I should feel comfortable?

Thanks for any advice, I'll also be asking a question on the breeder in that forum section.

**JakodaCD OA** · 01-10-2012, 06:25 PM

I would ask what the female they are breeding to has tested out as..If normal/normal as well , it means they don't carry the gene for it, but I don't think its a solid guarantee against it. Just stacking the deck in the favor of the puppies.

You would want to know the results on 'both' dogs, not just one

gagsd · 01-10-2012, 06:32 PM

If you know that one parent is n/n..... Then NONE of the puppies would develop DM even if the breeding partner is an at risk (2 genes for DM).

This is based on current knowledge, and may change if some of the throes I have heard about 2 types of DM were to be found true.

**JakodaCD OA** · 01-10-2012, 06:39 PM

Mary, thanks for clearing up,,I know with the MDR1 gene, (my aussie is a mutant/mutant),,,you could breed a normal/normal to a normal/mutant and come up with either..

So your saying if one parent was DM normal/normal and was bred to a dog that has the DM gene, the puppies still would be normal?

elisabeth_00117 · 01-10-2012, 06:49 PM

From what I understand...

If one parent is N/N then all pups from that say, sire, are to be clear of DM BUT can still be a carrier if bred with a dam that is N/A.

My Zefra comes from 2 N/N parents and Stark comes from a N/N sire and a N/A dam.

Zefra if and when bred, will be paired with a N/N dog to ensure those puppies have NO CHANCE at being N/A.

gagsd · 01-10-2012, 07:18 PM

Quote:

Originally Posted by JakodaCD OA

Mary, thanks for clearing up,,I know with the MDR1 gene, (my aussie is a mutant/mutant),,,you could breed a normal/normal to a normal/mutant and come up with either..

So your saying if one parent was DM normal/normal and was bred to a dog that has the DM gene, the puppies still would be normal?

The puppies would not be affected, but could be carriers, if one parent was n/n and the other a/a.

**JakodaCD OA** · 01-10-2012, 07:19 PM

ahh ok got it

thanks

ok, lets say the puppy ended up being a 'carrier', so that puppy if bred, could pass it on correct?

gagsd · 01-10-2012, 07:30 PM

Only if bred to n/a or a/a. If bred to an n/n then all resultings pups would again not be affected.

**JakodaCD OA** · 01-10-2012, 07:31 PM

cool, got it..so it is rather different than the mdr1 gene..

gagsd · 01-10-2012, 07:37 PM

So now I will have to go learn about the mdr1 inheritance

.

01-10-2012, 04:21 PM	#1 (permalink)
pwinters New Member Join Date: Jan 2012 Posts: 6	DM and Breeding Hi, new to the forum. What great information I've found here. Forgive me if I ask a question already asked. I tried searching but the results for DM were overwhelming. We lost our GSD to DM last year at the age of 7. It came on fast and was aggressive. I do not want to go through that again. My question, there is a breeder in my area who has their male listed as gene tested with a DM result of normal/normal. From another post I found, would this indicate that in the worst case, a puppy I receive from their litter would only be a carrier? And if I had no plans of breeding, I should feel comfortable? Thanks for any advice, I'll also be asking a question on the breeder in that forum section.

01-10-2012, 06:25 PM	#2 (permalink)
JakodaCD OA Moderator Join Date: May 2000 Location: Old Lyme, CT USA Posts: 14,237	I would ask what the female they are breeding to has tested out as..If normal/normal as well , it means they don't carry the gene for it, but I don't think its a solid guarantee against it. Just stacking the deck in the favor of the puppies. You would want to know the results on 'both' dogs, not just one __________________ Diane Danger Danger vom Kleinen Hain aka Masi "Angel" Jakoda's Bewitchen Sami CD OA OAJ OAC NGC OJC RS-O GS-N JS-O TT HIC CGC "Angel" Steinwald's Four x Four CGC HIC TT Harmonyhill's Hy Jynx NA NAJ NAC NJC RS-N JS-N HIC Jakoda's Jagged Edge

01-10-2012, 06:32 PM	#3 (permalink)
gagsd Knighted Member Join Date: Apr 2003 Location: georgia Posts: 2,972	If you know that one parent is n/n..... Then NONE of the puppies would develop DM even if the breeding partner is an at risk (2 genes for DM). This is based on current knowledge, and may change if some of the throes I have heard about 2 types of DM were to be found true. __________________ Animals do not have rights. Owners have responsibilities. www.columbusworkingdogs.com

01-10-2012, 06:39 PM	#4 (permalink)
JakodaCD OA Moderator Join Date: May 2000 Location: Old Lyme, CT USA Posts: 14,237	Mary, thanks for clearing up,,I know with the MDR1 gene, (my aussie is a mutant/mutant),,,you could breed a normal/normal to a normal/mutant and come up with either.. So your saying if one parent was DM normal/normal and was bred to a dog that has the DM gene, the puppies still would be normal? __________________ Diane Danger Danger vom Kleinen Hain aka Masi "Angel" Jakoda's Bewitchen Sami CD OA OAJ OAC NGC OJC RS-O GS-N JS-O TT HIC CGC "Angel" Steinwald's Four x Four CGC HIC TT Harmonyhill's Hy Jynx NA NAJ NAC NJC RS-N JS-N HIC Jakoda's Jagged Edge

01-10-2012, 06:49 PM	#5 (permalink)
elisabeth_00117 Crowned Member Join Date: May 2009 Location: Waterloo, Ontario Posts: 7,251	From what I understand... If one parent is N/N then all pups from that say, sire, are to be clear of DM BUT can still be a carrier if bred with a dam that is N/A. My Zefra comes from 2 N/N parents and Stark comes from a N/N sire and a N/A dam. Zefra if and when bred, will be paired with a N/N dog to ensure those puppies have NO CHANCE at being N/A. __________________ Battleborn Hundesport Wild Winds Archangel Raphael "Stark", HIC (2009-04-10) Wild Winds Zephyr "Zefra" (2011-04-15) *Beau* 03/08/97 to 06/07/10

01-10-2012, 07:19 PM	#7 (permalink)
JakodaCD OA Moderator Join Date: May 2000 Location: Old Lyme, CT USA Posts: 14,237	ahh ok got it thanks ok, lets say the puppy ended up being a 'carrier', so that puppy if bred, could pass it on correct? __________________ Diane Danger Danger vom Kleinen Hain aka Masi "Angel" Jakoda's Bewitchen Sami CD OA OAJ OAC NGC OJC RS-O GS-N JS-O TT HIC CGC "Angel" Steinwald's Four x Four CGC HIC TT Harmonyhill's Hy Jynx NA NAJ NAC NJC RS-N JS-N HIC Jakoda's Jagged Edge Last edited by JakodaCD OA; 01-10-2012 at 07:20 PM. Reason: added

01-10-2012, 07:30 PM	#8 (permalink)
gagsd Knighted Member Join Date: Apr 2003 Location: georgia Posts: 2,972	Only if bred to n/a or a/a. If bred to an n/n then all resultings pups would again not be affected. __________________ Animals do not have rights. Owners have responsibilities. www.columbusworkingdogs.com

01-10-2012, 07:31 PM	#9 (permalink)
JakodaCD OA Moderator Join Date: May 2000 Location: Old Lyme, CT USA Posts: 14,237	cool, got it..so it is rather different than the mdr1 gene.. __________________ Diane Danger Danger vom Kleinen Hain aka Masi "Angel" Jakoda's Bewitchen Sami CD OA OAJ OAC NGC OJC RS-O GS-N JS-O TT HIC CGC "Angel" Steinwald's Four x Four CGC HIC TT Harmonyhill's Hy Jynx NA NAJ NAC NJC RS-N JS-N HIC Jakoda's Jagged Edge

01-10-2012, 07:37 PM	#10 (permalink)
gagsd Knighted Member Join Date: Apr 2003 Location: georgia Posts: 2,972	So now I will have to go learn about the mdr1 inheritance. __________________ Animals do not have rights. Owners have responsibilities. www.columbusworkingdogs.com

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