Is Pano Genetic?

[Mikelia]

My Pano dog was raised in the city, quite close to the dupont plant which dumps a LOT of waste into the lake. So might be on to something there lol. My childhood dog started the pano problems when we were in the country though.
Eli was never fed puppy food, started with Innova Evo (before P&G owned it) which is quite similar to Orijen. This is what he was fed up until the Pano started. Eventually we tried some lower protein holistic foods. Tried some supplements. Kept getting pano bouts. Then did a ton of research on specific ingredients to avoid, calcium, phosphorus, selenium, magnesium etc... levels, did a ton more research trying to find a food that matched that, fed that food for 6 months and his poops were great but the pano bouts never stopped until he finally stopped growing. However he is a very big boy and was always a big puppy. Thick bones and grew fast - although steadily. He was 95lbs the last time I weighed him, and has always been kept quite lean.
I am always exctied about pano discussions hoping to figure out the answer some day.