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Alena Gonzalez 06-26-2014 10:19 PM

MDR1 mutation
So do I need to have my puppy tested for this before using heart worm preventative?

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gsdsar 06-26-2014 10:26 PM

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No. The amount of drug in HW preventatives is not enough to cause an issue.

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GatorBytes 06-26-2014 11:35 PM


Originally Posted by gsdsar (Post 5696593)
No. The amount of drug in HW preventatives is not enough to cause an issue.

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...which depends on the individual dog

So yes

my boy diesel 06-27-2014 01:19 AM

no because as gsdsar said the amt in there is so slight even mdr1 positive dogs such as aussies can safely tolerate it
it is up to you but it is not necessary

says here

Fortunately, the dose of ivermectin, selamectin, milbemycin and moxidectin in the commercial heartworm preparations are low enough to be used safely even in dogs with the MDR1 mutation.

btw this is from the same college that isolated the mdr1 gene and do the testing so it is quite accurate :)

JeanKBBMMMAAN 06-27-2014 07:52 AM

That link from diesel is the one to read.

IF your dog were being treated for mange, then yes, that amount of medication is enough to trip the MDR1 trigger.

When you have your dog spayed or neutered, and before surgeries, you can test or ask them to use meds not on the list (I have a little herding breed mix and I am just calling him a mutant without testing).

If your dog eats livestock feces and those animals are treated with Ivermectin, that can be enough to trip the mutant trigger.

To be safe with herding breeds, you avoid things like Immodium and the other drugs on the list.

But to start a puppy on hw meds, gsdsar is correct. Also the meds have to be given monthly for a reason - they do not accumulate in the system to create a giant dose of ivermectin at the end of the year that suddenly kills the dog. Just don't use the injectible. Talk to your vet, as always.

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