Health testing would be my biggest concern, but I would want to know why the parents didn't have titles. Some experienced breeders have valid reasons for breeding untitled dogs (occasionally). Breeders who NEVER title their dogs, though, are another matter entirely- to me personally, it says they don't want to invest the time or money and don't know their dogs as well as someone who has been through the paces with them. Of course, then you get into folks who import already titled dogs, etc.... so it's kind of a rabbit hole.
It's not a deal breaker, I'd just want to know why.