Wait until she is done her cycle.
And I agree don't let her loose. If she has proven to be an escape artist in the past don't leave her in the yard alone and risk her getting out and finding a handsome boyfriend.
I never spay any of our girls as we are breeders so all of our girls have "panties" that we line with panty liners to avoid getting blood on the furniture etc. Be sure to change the pads as needed to avoid infections.
If her brother is an intact male then I would suggest keeping them separated as well, otherwise you may end up with some illegitimate love puppies
Good luck with your girl
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