Do you mean pepper spray? They work with most dogs I'd imangine, but the type that spray out in a cone like bear spray can affect you too if there's a wind. They make one that shoots a stream, less likely to get yourself, but a little harder to hit the target. We had an incident last night with a herd of mutant Chihuahuas, had all could do to keep the two aggressive ones from biting me and my dog. A handful of gravel works great, but there was none around. I don't know about you, but I'm still PO a day later.