I always try a cure first which is a departure from the norm...as long as the condition allows for it.
Have you tried any of these ideas?
Natural Cures for Pyoderma in Dogs
I'm a fan of using apple cider vinegar for many remedies for humans...I noticed ACV was also listed as an ingredient in "natural " cures for pyoderma.
I wish I could say I have firsthand knowledge of the efficacy of more natural remedies for pyoderma...but I do not.
Best of luck,