My dogs - outside of the puppy - have had two doses of it. One when they were part of the taste testing phase, and they got one this past month before we went out on a hike because we had already started pulling ticks off and I was lazy about using Frontline since my dogs get wet basically daily lol.
Given that I found three dead ticks about my room (the american dog tick is pretty common here), it definitely works to my experience.
None of the dogs have had any issues with it either. I like the company personally. They seem to make some of the safer products out there, IME.
Cost is always the downside of a new product, but with all the concern about Trifexis, they definitely have a corner of the market with this one.