Yes..it does. I'm sorry I didn't mention that. Here's my story. I had a JRT (RIP Jack Daniels) that had used Frontline his entire life. All of a sudden he and my house were infested with fleas. I tried everything from Boric Acid to DE./ I had an inch of DE all over my house
Turns out the fleas were smarter than the Frontline and my vet recommended Comfortis. Within 2 weeks every flea on the dog and more importantly in the house, were gone! A year or so after that Trifexis came on the market so we switched to that. I love it.