As others have said - take her out and WAIT for her to potty then lots of praise and bring her back inside.
Once inside the puppy should either be in a crate or your wife should be 100% aware of where the pup is at all times. The easiest way to do this is to put the puppy on leash and have your wife attach the other end of the leash to her waist.
When a puppy has an accident in the house it's not the puppy's fault - it's the HUMANS fault for not watching the puppy.
Lauri & The Raw Fed Gang
Raw Dog Ranch
Winnie CGC - Corgi Mix
Chimanes Spice it Up Piquin (Kaynya) - Chinese Crested
Nator von Triton
HIC CGC (Mauser) - LC GSD
Piquins Some Like it Hot (Spike) – Chinese Crested
Piquins Too Hot To Handle - (Fuego) - Chinese Crested
Piquins Wasabi (Sabi) - Chinese Crested
Piquins Super Hot (Clark) - Chinese Crested
Banzai, Cloe, Mocha - Felines Extraordinaire
Neke, Tessa, Remi, Sadie, Riggs, Sasha, Tazer - DK, Mozart, Zoe - Gone but not forgotten