I suppose that would all depend on how much of a change you are wanting to make. I went from a high paying, high stress, never home type position to a lower paying, lower stress, close to home type of job. I am basically doing the same thing, just at a different level.
For me, it was a great decision.
If you are wanting to go from a heart surgeon to a cookie baker, then that is a BIG change. It would require a great deal of soul searching.
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